JCI - Hypercholesterolemia decreases nitric oxide

Measurements of NO release revealed that the LDL subfraction alone mimicked the effect obtained with the HC serum: basal and stimulated NO production were inhibited when compared with the results obtained from endothelial cells exposed to the NC serum or to LPDS supplemented with any of the non-LDL subfractions (Fig. (Fig.4 4 b). The ratio of stimulated vs. basal NO production, which was 2.1:1 LDL subclasses Discussion LDL subclasses were similar in all groups of animals studied (25.9 ± 0.3 nm, 25.0 ± 0.6 nm, 25.7 ± 0.5 nm, and 25.6 ± 0.4 nm The presence of dyslipidemia is common in renal diseases and in C, DefC, NS, and DefNS, respectively, ANOVA p = not sig- may contribute to the higher incidence of coronary artery nificant plemented with any of the non-LDL subfractions (Fig. 4 b). The ratio of stimulated vs. basal NO production, which. was 2.1:1 in cells exposed to NC serum, was attenuated to . 1.6:1 and 1.5:1 in Introduction The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. LDL particles after therapy were changed in composition to contain less lipid relative to protein, Differences in low density lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal women. J Clin Endocrinol Metab. 1988; 67:30-35. Crossref Medline Google Scholar; 13 Brown SA, Hutchinson R, Morrisett JD, Boerwinkle E, Davis CE, Gotto AM, Patsch W. Plasma lipid LDL is a particle, heterogeneous in size, density, electric Deficient diet (Teklad TD84253) charge, and composition. The smaller and denser particles are Torula yeast 300 30 Sucrose 595 59.5 more susceptible to oxidation [9]. Vitamin E and selenium are Lard, Tocopherol-stripped 50 5.0 important factors in the protection of lipids from oxidation [10]. dl-Methionine 3 0.3 Vitamin E is Measurements of NO release revealed that the LDL subfraction alone mimicked the effect obtained with the HC serum: basal and stimulated NO production were inhibited when compared with the results obtained from endothelial cells exposed to the NC serum or to LPDS supplemented with any of the non-LDL subfractions (Fig. 4b). The ratio of stimulated vs. basal NO production, which was 2.1:1 in LDL particles separation was performed by electrophoretic Lipoprint System (Quantimetrix Inc., Redondo Beach, CA). The proportion of sd-LDL particles (subfractions 3–7) to the whole LDL area (subfractions 1–7) was calculated and reported as LDL score, with higher score values representing a higher sd-LDL particles content . Berlin - Germany; Fort Worth - United States; Hamburg - Germany; Milan - Italy; Madrid - Spain; San Diego - United States Karabina et al. have reported that the extent of formation of this oxidation product is greater in dense LDL subfractions and that this is associated with increased platelet activating factor acetylhydrolase. These observations suggest that the pathophysiological process potentiated by lysophosphatidylcholine could be enhanced by oxidised forms of dense LDL. Small, dense LDL particles are less

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